Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lifestyle modification and endothelial function in obese subjects.

Osama Hamdy1

  • 1Joslin Diabetes Center, Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA. Osama.Hamdy@joslin.harvard.edu

Expert Review of Cardiovascular Therapy
|April 28, 2005
PubMed
Summary

Lifestyle modifications, including diet and exercise, can improve endothelial function and insulin sensitivity. These changes help manage metabolic syndrome and Type 2 diabetes, reducing cardiovascular risks in obese individuals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-Term Effects of Intensive Lifestyle Intervention on Cardiometabolic Outcomes in Patients With Diabetes in Real-World Clinical Practice: A 15-Year Longitudinal Study.

Journal of diabetes·2025
Same author

Management of Diabetic Wounds: Expert Panel Consensus Statement.

Advances in wound care·2025
Same author

Effect of Almond Milk Versus Cow Milk on Postprandial Glycemia, Lipidemia, and Gastrointestinal Hormones in Patients with Overweight or Obesity and Type 2 Diabetes: A Randomized Controlled Clinical Trial.

Nutrients·2025
Same author

Nutrition Interventions for Remission of Type 2 Diabetes: Potential Role for Diabetes-Specific Nutrition Formulas.

Clinical diabetes : a publication of the American Diabetes Association·2025
Same author

Is Weight Loss the Main Driver for A1C Improvement by Glucagon-Like Peptide 1 (GLP-1) Receptor Agonists? A 2.5-Year Analysis in Real-World Clinical Practice.

Journal of diabetes·2025
Same author

A Randomized Trial Comparing Inhaled Insulin Plus Basal Insulin Versus Usual Care in Adults With Type 1 Diabetes.

Diabetes care·2024

Area of Science:

  • Cardiovascular Science
  • Metabolic Science
  • Endocrinology

Background:

  • Metabolic syndrome involves obesity, insulin resistance, and hypertension, leading to cardiovascular disease.
  • Endothelial dysfunction is an early sign of atherosclerosis, seen in obesity and diabetes.
  • Adipocytes secrete adipokines (leptin, adiponectin, TNF-α, IL-6, resistin) linking insulin resistance and cardiovascular disease.

Purpose of the Study:

  • To review the role of lifestyle modifications in reducing cardiovascular risk.
  • To discuss the impact of lifestyle changes on metabolic syndrome and Type 2 diabetes.
  • To explore how lifestyle interventions affect endothelial function and adipokine levels.

Main Methods:

  • Literature review of recent studies.

Related Experiment Videos

  • Analysis of the effects of caloric restriction and physical activity.
  • Examination of impacts on endothelial function, insulin sensitivity, and adipocytokines.

    • Main Results:

    • Lifestyle modifications improve endothelial function and insulin sensitivity.
    • Interventions can alter serum adipokine levels.
    • Lifestyle changes are crucial for managing metabolic syndrome and Type 2 diabetes.

    Conclusions:

    • Lifestyle modification is a primary treatment for individuals at risk.
    • Improving endothelial and adipose tissue function may reduce cardiovascular events.
    • Lifestyle interventions show promise in ameliorating cardiovascular risk in obese subjects.