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Updated: Aug 18, 2026

Microfluidic Mixers for Studying Protein Folding
Published on: April 10, 2012
Folding and mis-folding of peptides and proteins: insights from molecular simulations
Giacomo M S De Mori1, Massimiliano Meli, Luca Monticelli
1Istituto di Chimica del Riconoscimento Molecolare, CNR, via Mario Bianco 9, 20131 Milano, Italy.
Abstract:
In this paper, the main achievements and problems of the application of all-atom molecular simulations, with particular attention for Molecular Dynamics (MD), will be critically reviewed. Starting from unfolding simulations, through biased simulations, which require a knowledge of the native state conformation, to folding studies based on the simple knowledge of the protein (or peptide) sequence, the strengths and weaknesses of theoretical approaches to the study of folding and their matching with experimental observations will be discussed. Finally, we will give a critical outlook on the possible developments of this field in the near future.
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