Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell therapy for inner ear diseases.

T Nakagawa1, J Ito

  • 1Department of Otolaryngology-Head and Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan. tnakagawa@ent.kuhp.kyoto-u.ac.jp

Current Pharmaceutical Design
|April 28, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MRI in essential primary cutis verticis gyrata.

Neuroradiology·2001
Same author

Anti-AIDS agents. 48.(1) Anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis.

Journal of natural products·2001
Same author

The relationship of primary tumor thickness in carcinoma of the tongue to subsequent lymph node metastasis.

Dento maxillo facial radiology·2001
Same author

Condylar bony change and self-reported parafunctional habits in prospective orthognathic surgery patients with temporomandibular disorders.

Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics·2001
Same author

Cytotoxic pheophorbide-related compounds from Clerodendrum calamitosum and C. cyrtophyllum.

Journal of natural products·2001
Same author

Synovial chondromatosis in the temporomandibular joint complicated by displacement and calcification of the articular disk: report of two cases.

AJNR. American journal of neuroradiology·2001

Cell therapy offers a promising avenue for treating irreversible inner ear cell degeneration, which causes hearing and balance disorders. Research shows transplanted stem cells can survive, differentiate, and potentially restore damaged inner ear cells.

Area of Science:

  • Oto-neurology
  • Regenerative Medicine
  • Cell Biology

Background:

  • Inner ear cell degeneration, particularly sensory hair cells and neurons, leads to incurable hearing impairment and balance disorders.
  • Current treatments are limited due to the irreversible nature of hair cell and neuron loss.
  • Regenerative strategies focusing on protection or regeneration are crucial for developing effective inner ear disease therapies.

Purpose of the Study:

  • To explore the potential of cell therapy for treating inner ear disorders.
  • To evaluate the feasibility of using various stem cells for inner ear repair and drug delivery.
  • To provide a foundation for developing novel therapeutic approaches for inner ear conditions.

Main Methods:

  • Investigated the use of neural stem cells (NSCs) for inner ear cell transplantation.

Related Experiment Videos

  • Examined the survival, differentiation, and therapeutic potential of grafted NSCs.
  • Reviewed studies on embryonic stem cells (ESCs), dorsal ganglion cells, and mesenchymal stem cells (MSCs) for inner ear applications.
  • Assessed the potential of cell transplantation for targeted drug delivery within the inner ear.

    • Main Results:

    • Grafted NSCs demonstrated survival and differentiation into neural, glial, and hair cell-phenotypes within the inner ear.
    • ESCs, dorsal ganglion cells, and fetal inner ear cell lines show potential for restoring damaged inner ear cells.
    • NSC-derived cells can produce neurotrophins, suggesting a role in inner ear repair.
    • Autologous bone marrow stromal cells (MSCs) exhibit high survival and migration, indicating their utility as drug delivery vehicles.

    Conclusions:

    • Cell transplantation, particularly using stem cells, presents a viable strategy for treating inner ear disorders.
    • Stem cell therapy holds promise for both regenerating damaged inner ear cells and facilitating targeted drug delivery.
    • Further research in cell transplantation provides a strong basis for developing future therapies for hearing and balance dysfunctions.