Mineralocorticoid resistance
Related Experiment Video
Updated: Aug 18, 2026

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
Published on: December 9, 2015
1Section of Nephrology, Yale University School of Medicine, New Haven, CT 06520-8029, USA. david.geller@yale.edu
Abstract:
The mineralocorticoid aldosterone plays a crucial role in regulation of volume and electrolyte homeostasis. In recent years there has been considerable progress in deciphering the role of aldosterone in human physiology by the study of monogenic disorders exhibiting mineralocorticoid resistance. Although these disorders are rare, the elucidation of their molecular basis has yielded many insights into aldosterone biology that are proving relevant to the care of patients with a wide variety of cardiovascular diseases. Recent advances in understanding the molecular basis of syndromes of mineralocorticoid resistance are reviewed with a view towards an improved understanding of the role of aldosterone in renal sodium transport and its relationship to cardiovascular disease.
Related Concept Videos
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Heart Failure Drugs: Diuretics
Antihypertensive Drugs: Potassium-Sparing Diuretics
Antihypertensive Drugs: Angiotensin II Receptor Blockers
Heart Failure II: Pathophysiology
Heart Failure Drugs: β-Blockers
