Gender-dependent effect of ageing on peripheral insulin action
A-M Borissova1, T Tankova, G Kirilov
1Clinical Centre of Endocrinology, Medical University, Sofia, Bulgaria. blpo98@internet-bg.net
International Journal of Clinical Practice
|April 28, 2005
Summary
Gender and age significantly impact insulin sensitivity and receptor binding. Females exhibit higher insulin sensitivity, while males have more insulin receptors, with both sexes showing decreased sensitivity with age.
Area of Science:
- Endocrinology
- Metabolism
- Human Physiology
Background:
- Insulin resistance is a growing health concern.
- Understanding factors influencing insulin action is crucial for metabolic health.
- Gender and age are known demographic factors that can influence physiological processes.
Purpose of the Study:
- To investigate the effects of gender and age on insulin secretion.
- To examine the influence of gender and age on peripheral insulin effectiveness.
- To analyze the impact of gender and age on insulin-receptor binding.
Main Methods:
- Study included 80 healthy volunteers (40 females, 40 males).
- Peripheral insulin effectiveness was measured using the euglycaemic hyperinsulinaemic clamp technique.
- Insulin-receptor binding was assessed on circulating mononuclear blood cells.
Main Results:
- Females showed significantly higher peripheral insulin sensitivity than males (p < 0.001).
- Males had a higher total number of insulin receptors (p < 0.0001) and high-affinity receptors (p < 0.01).
- Peripheral insulin sensitivity decreased with age in both genders, more pronounced in females (p < 0.05).
- Age-related changes in insulin sensitivity and receptor binding differed between genders, potentially linked to hormonal variations.
Conclusions:
- Gender and age are critical factors influencing peripheral insulin effectiveness and insulin-receptor binding.
- Differences in insulin sensitivity between genders may be related to hormonal influences on post-receptor insulin action.
- Age-related decline in insulin sensitivity is more significant in females.
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