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Related Experiment Videos

The pupillary light reflex in migraine.

Deacon E Harle1, James S Wolffsohn, Bruce J W Evans

  • 1The Neville Chappell Research Clinic, The Institute of Optometry, London. dharle@ioo.org.uk

Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)
|April 28, 2005
PubMed
Summary

Migraine sufferers show subtle pupil abnormalities, specifically in light response latency, even between headaches. These pupil changes correlate with headache side but not frequency or severity.

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Area of Science:

  • Ophthalmology
  • Neurology

Background:

  • Existing literature suggests potential pupil abnormalities in individuals with migraine headaches.
  • Pupil responses to light may offer insights into the underlying pathophysiology of migraine.

Purpose of the Study:

  • To investigate dynamic pupil responses to light in migraine sufferers during non-headache periods.
  • To compare pupil responses between migraine patients and healthy controls.
  • To explore correlations between pupil abnormalities and headache characteristics.

Main Methods:

  • Utilized an infra-red pupillometer to measure dynamic pupil light responses.
  • Recruited 20 migraine sufferers (inter-ictal phase) and 16 age/gender-matched controls.
  • Analyzed inter-ocular differences in pupil light response latency and anisocoria.

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Main Results:

  • Migraine group exhibited a significant increase in the absolute inter-ocular difference of pupil light response latency compared to controls (0.062 s vs 0.025 s, p = 0.014).
  • A significant correlation was found between anisocoria and the habitual side of headache pain (r = 0.59, p < 0.01).
  • No significant correlation was observed between pupil changes and headache interval, severity, or annual frequency.

Conclusions:

  • Subtle sympathetic and parasympathetic pupil abnormalities persist in the inter-ictal phase of migraine.
  • These findings suggest ongoing neurological changes affecting pupillary function between migraine attacks.