Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mammalian hormones in microbial cells.

J Lenard1

  • 1UMDNJ, Robert Wood Johnson Medical School (at Rutgers), Department of Physiology and Biophysics, Piscataway 08854-5635.

Trends in Biochemical Sciences
|April 1, 1992
PubMed
Summary

Hormone-like substances and proteins are found in microbes like fungi and bacteria. These findings suggest the vertebrate endocrine system

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The m protein of vesicular stomatitis virus: variability in lipid-protein interaction compatible with function.

Biophysical journal·2009
Same author

Male and female car drivers--differences in collision and injury risks.

Annual proceedings. Association for the Advancement of Automotive Medicine·2002
Same author

Host cell protein kinases in nonsegmented negative-strand virus (mononegavirales) infection.

Pharmacology & therapeutics·1999
Same author

The transmembrane domain in viral fusion: essential role for a conserved glycine residue in vesicular stomatitis virus G protein.

Proceedings of the National Academy of Sciences of the United States of America·1998
Same author

Lower limb injuries to passenger car occupants.

Accident; analysis and prevention·1997
Same author

Characterization of cholesterol-free insect cells infectible by baculoviruses: effects of cholesterol on VSV fusion and infectivity and on cytotoxicity induced by influenza M2 protein.

Experimental cell research·1997

Area of Science:

  • Microbiology
  • Endocrinology
  • Evolutionary Biology

Background:

  • Hormones and hormone-binding proteins are crucial for vertebrate physiological regulation.
  • The evolutionary origins of hormonal systems are generally considered to be within vertebrates.

Purpose of the Study:

  • To investigate the presence and potential function of hormone-like molecules in microbial organisms.
  • To explore the evolutionary implications of these findings for the vertebrate endocrine system.

Main Methods:

  • Comparative analysis of molecular structures in microbial and vertebrate systems.
  • Functional assays to determine microbial responses to mammalian hormones.

Main Results:

  • Discovery of hormone and hormone-binding protein homologs in fungi, yeast, and bacteria.
  • Demonstration of functional responses in microbial cells to mammalian hormones.

Conclusions:

  • The presence of hormone-like molecules and functions in microbes predates vertebrates.
  • The evolutionary roots of the vertebrate endocrine system may be significantly more ancient than previously understood.

Related Experiment Videos