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Related Experiment Videos

Fluorescence-based glucose sensors.

John C Pickup1, Faeiza Hussain, Nicholas D Evans

  • 1Department of Chemical Pathology, Guy's, King's and St Thomas's School of Medicine, Guy's Hospital, London SE1 9RT, UK. john.pickup@kcl.ac.uk

Biosensors & Bioelectronics
|April 28, 2005
PubMed
Summary
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Continuous glucose monitoring is crucial for diabetes management. Fluorescence-based sensors offer sensitive, potentially non-invasive methods for glucose detection, overcoming limitations of electrochemical devices.

Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Diabetes Technology

Background:

  • Existing electrochemical glucose monitoring devices face limitations.
  • There is a critical need for continuous in vivo glucose monitoring in diabetes mellitus.
  • Fluorescence-based sensing presents an alternative with advantages in sensitivity and non-invasive potential.

Purpose of the Study:

  • To review the principles, context, and current status of fluorescence-based glucose sensing technologies.
  • To highlight the advantages of fluorescence sensing over electrochemical methods.
  • To explore various receptor and technique combinations for glucose detection.

Main Methods:

  • Utilizing fluorescence intensity and lifetime measurements.
  • Employing various glucose receptors: lectins (Concanavalin A), enzymes (glucose oxidase, dehydrogenase, hexokinase), bacterial glucose-binding protein, and boronic acid derivatives.

Related Experiment Videos

  • Implementing techniques like Förster Resonance Energy Transfer (FRET) and measuring intrinsic/extrinsic fluorophore changes.
  • Exploring cell autofluorescence (NAD(P)H) and mitochondrial metabolism markers for non-invasive monitoring.

    • Main Results:

    • Fluorescence sensors demonstrate high sensitivity for glucose detection.
    • Near-infrared light enables potential for non-invasive glucose monitoring.
    • Diverse receptor-fluorophore systems are being developed for specific applications.
    • Changes in fluorescence resonance energy transfer (FRET) and intrinsic/extrinsic fluorescence signal glucose presence.

    Conclusions:

    • Fluorescence-based glucose sensing offers a promising alternative to electrochemical methods.
    • Continued development in receptor design and optical techniques will advance continuous, non-invasive glucose monitoring.
    • These technologies hold significant potential for improved diabetes management.