Related Experiment Video
Updated: Aug 17, 2026
Nonhuman Primate Lung Decellularization and Recellularization Using a Specialized Large-organ Bioreactor
Published on: December 15, 2013
Histopathologic findings in a novel decellularized pulmonary homograft: an autopsy study
Friedhelm Sayk1, Inge Bos, Ute Schubert
1Institute of Pathology, University of Luebeck, Luebeck, Germany. friedhelm.sayk@innere1.uni-luebeck.de
Abstract:
Innovative valved conduits for reconstruction of the right ventricular outflow tract are desirable to overcome the risk of valve deterioration of conventional homografts. This study describes the histopathology of a novel decellularized pulmonary homograft (SynerGraft) implanted in the right ventricular outflow tract of a 60-year-old man 5 weeks before death. The histomorphology of this decellularized homograft showed integrity of its extracellular matrix and a gradual cellular infiltrate consisting predominantly of macrophages, resembling an early nonspecific inflammatory phase of recellularization without any signs of a specific immunologic interference 5 weeks after implantation. Whether this morphologic appearance precedes the desired repopulation with autologous fibroblasts remains to be established.
