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Updated: Aug 18, 2026

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement
Published on: March 26, 2018
Internal thoracic artery: to skeletonize or not to skeletonize?
Shahzad G Raja1, Gilles D Dreyfus
1Department of Cardiac Surgery, Alder Hey Hospital, Liverpool, United Kingdom. drrajashahzad@hotmail.com
Insights
Skeletonization of the internal thoracic artery (ITA) provides longer grafts for coronary artery bypass grafting, potentially improving outcomes. Further randomized trials are needed to confirm its long-term safety and efficacy compared to traditional methods.
Area of Science:
- Cardiovascular Surgery
- Thoracic Surgery
- Vascular Grafting
Background:
- The internal thoracic artery (ITA) is a preferred graft in coronary artery bypass grafting (CABG) due to its superior long-term patency.
- Achieving adequate graft length is crucial for complete myocardial revascularization.
- The skeletonization technique aims to increase ITA graft length.
Purpose of the Study:
- To evaluate the safety and efficacy of the skeletonization technique for harvesting the internal thoracic artery (ITA) in coronary artery bypass grafting (CABG).
- To assess the potential benefits of skeletonized ITA grafts, including increased length and reduced complications.
- To identify the need for further research comparing skeletonized and pedicled ITA grafts.
Main Methods:
- Review of existing retrospective studies (level 3 evidence) on the skeletonization technique for ITA harvesting.
- Comparison of skeletonized ITA grafts with traditional pedicled grafts in CABG.
- Analysis of graft patency, surgical complications, and long-term patient outcomes.
Main Results:
- Skeletonization allows for longer ITA conduits, potentially improving free flow and reducing sternal/pulmonary complications.
- Concerns regarding vasoreactivity, surgical trauma, and vasa vasorum perfusion persist.
- Current evidence suggests skeletonization is safe and effective for myocardial revascularization.
Conclusions:
- Skeletonization of the ITA is a promising technique for enhancing graft length in CABG.
- Further multicenter, randomized controlled trials are essential to definitively establish the long-term patency and efficacy of skeletonized ITA grafts.
- High-quality evidence is needed to universally accept the skeletonization technique over the pedicled approach.
Abstract:
The internal thoracic artery has been the most reliable graft material used in coronary artery bypass grafting with an excellent long-term patency rate. Complete myocardial revascularization with internal thoracic arteries improves long-term survival and decreases the rate of repeat operations compared with vein grafts. Adequate length of the graft in coronary artery bypass graft surgery is essential for providing complete arterial revascularization. In the last decade or so, technique of skeletonization of internal thoracic artery has been proposed to achieve extra length. Skeletonization of the internal thoracic artery allows the preparation of longer conduits with a superior free flow and can reduce the incidence of postoperative pulmonary and sternal complications. However, concerns about vasoreactivity of skeletonized internal thoracic artery grafts, the functional consequences of surgical trauma, the possible loss of innervation, and vasa vasorum perfusion in the skeletonized conduits have prevented this technique from being universally accepted. Presently available evidence from retrospective studies (level 3 evidence) suggests that skeletonization is a safe and effective technique for myocardial revascularization. However, there is a need for conducting multicenter, randomized controlled trials comparing the skeletonized and pedicled internal thoracic arteries with special emphasis on long-term patency to conclusively validate the safety and efficacy of skeletonization technique.
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