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Molecularly targeted therapies for breast cancer

Timothy J Hobday1, Edith A Perez

  • 1Department of Oncology, Mayo Clinic, Jacksonville, FL 32224, USA.

Cancer Control : Journal of the Moffitt Cancer Center
|April 28, 2005
PubMed
Abstract

Insights

New targeted therapies are emerging for breast cancer treatment. These innovative treatments aim to improve patient selection and expand effective therapeutic options for both localized and advanced disease.

Area of Science:

  • Oncology
  • Pharmacology
  • Genetics

Background:

  • Breast cancer management is evolving, with current therapies like chemotherapy, endocrine therapy, and trastuzumab having limitations.
  • Understanding cancer cell-specific aberrations drives the development of targeted therapies.
  • The goal is to improve treatment efficacy through precise patient selection.

Purpose of the Study:

  • To review promising targeted therapies currently in clinical development for breast cancer.
  • To provide an overview of agents undergoing phase I, II, and III clinical trials.

Main Methods:

  • Computerized literature search.
  • Manual search of selected meeting abstracts.

Main Results:

  • Several targeted therapies are in Phase III clinical trials for breast cancer.
  • Numerous other agents are progressing through Phase I and II testing.
  • The study discusses the most promising agents in clinical development.

Conclusions:

  • Targeted therapy is a current reality in breast cancer treatment.
  • New agents show promise for expanding and refining patient benefit.
  • Future developments aim to enhance personalized treatment approaches.

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