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Diffuse choroid plexus hyperplasia: an under-diagnosed cause of hydrocephalus in children?

Azian Abd Aziz1, Lee Coleman, Andrew Morokoff

  • 1Department of Medical Imaging, The Royal Children's Hospital Melbourne, Flemington Road, Parkville, Victoria, 3052, Australia.

Pediatric Radiology
|April 28, 2005
PubMed

Insights

Diffuse villous hyperplasia of the choroid plexus is a rare cause of hydrocephalus in children. Surgical resection of the hyperplastic choroid plexus is the recommended treatment, not shunt insertion.

Area of Science:

  • Pediatric Neurology
  • Neurosurgery
  • Histopathology

Background:

  • Hydrocephalus is a common neurological disorder in children with diverse etiologies.
  • Advancements in imaging, like MRI, aid in identifying rarer causes.
  • Congenital aqueduct stenosis was the initial diagnosis for the patient's hydrocephalus.

Observation:

  • An 11-year-old boy presented with shunt dysfunction.
  • Imaging revealed enlarged choroid plexuses but did not confirm aqueduct stenosis.
  • Cerebrospinal fluid (CSF) overproduction was confirmed via externalized ventricular drain.

Findings:

  • Diffuse villous hyperplasia of the choroid plexus was surgically resected.
  • Histological examination confirmed choroid plexus hyperplasia.
  • This finding challenged the initial diagnosis of aqueduct stenosis.

Implications:

  • Choroid plexus hyperplasia represents a distinct cause of pediatric hydrocephalus.
  • Neurosurgical management should prioritize resection of hyperplastic choroid plexus over shunt placement.
  • Accurate diagnosis is crucial for effective treatment of hydrocephalus.

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