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Updated: Aug 9, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Topical therapies for psoriasis: evidence-based review
Tarek Afifi1, Gillian de Gannes, Changzheng Huang
1Division of Dermatology, Vancouver, BC.
Canadian Family Physician Medecin De Famille Canadien
|April 29, 2005
Summary
Topical treatments for psoriasis, including corticosteroids, vitamin D analogues, and topical retinoids, offer effective options for managing mild to moderate disease. Combining therapies may enhance efficacy and reduce side effects.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Psoriasis is a prevalent skin condition causing significant morbidity.
- Topical therapies are well-suited for managing mild to moderate psoriasis.
- Advances in understanding psoriasis pathogenesis drive new treatment development.
Purpose of the Study:
- To review current topical psoriasis therapies.
- To assess the efficacy and adverse effects of these treatments.
Main Methods:
- Literature review from 1987-2003 using MEDLINE.
- Search terms: "psoriasis" and "topical treatment."
- Prioritized double-blind, randomized controlled trials; included other Level I studies if necessary.
Main Results:
- Corticosteroids remain a first-line therapy for psoriasis.
- Vitamin D analogues and topical retinoids demonstrate comparable efficacy to corticosteroids.
- These alternatives may present a slight increase in adverse effects.
Conclusions:
- Combination therapy, particularly steroids with vitamin D analogues or topical retinoids, shows promise.
- Combined treatments may offer increased efficacy and improved side effect profiles.
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