Related Experiment Video
Updated: Aug 18, 2026
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
High sensitive C-reactive protein: a novel biochemical markers and its role in coronary artery disease
1Department of Internal Medicine, Institute of Post Graduate Medical Education and Research, SSKM Hospital, Kolkata.
Insights
High-sensitivity C-reactive protein (hs-CRP) elevation predicts long-term cardiovascular events independently of traditional risk factors. hs-CRP can identify individuals who benefit most from preventive therapies.
Area of Science:
- Cardiovascular Medicine
- Inflammation Biomarkers
Background:
- Systemic inflammation is linked to cardiovascular disease (CVD) risk.
- High-sensitivity C-reactive protein (hs-CRP) is an inflammatory marker.
- Elevated hs-CRP indicates increased long-term cardiovascular event risk.
Purpose of the Study:
- To evaluate the predictive value of hs-CRP for cardiovascular events.
- To determine if hs-CRP offers advantages over traditional risk factors.
- To assess hs-CRP's role in guiding preventive therapies.
Main Methods:
- Analysis of prospective studies documenting hs-CRP levels.
- Comparison of hs-CRP predictive capacity against traditional cardiovascular risk factors.
- Review of data from PHS and CARE trials regarding preventive therapies.
Main Results:
- Mildly elevated baseline hs-CRP in healthy individuals predicts higher long-term cardiovascular events.
- hs-CRP's predictive power is independent of traditional risk factors.
- hs-CRP offers prognostic advantage over lipid measurements alone.
Conclusions:
- hs-CRP is a valuable biomarker for predicting future cardiovascular events.
- hs-CRP can identify individuals who may benefit from preventive therapies, including statins.
- Aggressive risk factor management is recommended for patients with documented CAD and high hs-CRP.
Abstract:
A series of prospective studies provide consistent data documenting that mild elevation of baseline levels of hs-CRP among apparently healthy individuals is associated with higher long-term risk for future cardiovascular events. This predictive capacity of hs-CRP is independent of traditional cardiovascular risk factors and offers a prognostic advantage over measurement of lipid alone. PHS and CARE trial suggest that the increased risk associated with systemic inflammation may be modified with certain preventive therapies and that inflammatory marker specifically hs-CRP may help to identify those who would benefit most from these pharmacological intervention. hs-CRP is the novel and evolving biomarker which provides a most useful predictive indicator for subsequent cardiovascular events. Based on various studies, increased hs-CRP levels in patients with high risk cardiovascular disease without documented CAD warrant treatment with statin even if LDL-C levels are within target range. Patients with documented CAD and high hs-CRP levels should be followed, and there risk factors should be managed aggressively.
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:30Acute Coronary Syndrome I: Introduction
01:30Coronary Artery Disease I: Introduction
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT