Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Classification and diagnostic criteria in systemic vasculitis.

Assil Saleh1, John H Stone

  • 1The Johns Hopkins Vasculitis Center, 5501 Hopkins Bayview Circle, 1B.23, Baltimore, MD 21224, USA.

Best Practice & Research. Clinical Rheumatology
|April 29, 2005
PubMed
Summary

Vasculitis classification schemes have evolved over 50 years, considering vessel size and disease features. However, robust diagnostic criteria for these autoimmune inflammatory conditions remain challenging to establish.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Obexelimab for the Treatment of IgG4-Related Disease.

The New England journal of medicine·2026
Same author

Secukinumab for Giant Cell Arteritis.

NEJM evidence·2026
Same author

Phase 3 Trial of Secukinumab in Polymyalgia Rheumatica.

The New England journal of medicine·2026
Same author

Broad screening of inflammation-associated proteins identifies serum CCL19 as a novel biomarker of disease activity in IgG4-related disease.

Annals of the rheumatic diseases·2026
Same author

Evaluation of steroid toxicity using the Glucocorticoid Toxicity Index-Metabolic Domains instrument in adults with myasthenia gravis: a real-world study in the USA.

Journal of comparative effectiveness research·2026
Same author

Efficacy and Safety of Obexelimab to Treat IgG4-Related Disease: Protocol for a Global, Randomized, Placebo-Controlled Trial.

Rheumatology and therapy·2026

Area of Science:

  • Rheumatology
  • Immunology
  • Internal Medicine

Background:

  • Over 20 primary forms of vasculitis exist, with varied classification approaches over the past 50 years.
  • Existing classification schemes consider vessel size, demographics, organ involvement, inflammation type, immune complexes, and autoantibodies.
  • Despite advancements, substantial knowledge gaps persist, impacting comprehensive classification and diagnosis.

Purpose of the Study:

  • To review the evolution and limitations of vasculitis classification schemes.
  • To highlight the utility of American College of Rheumatology criteria in research.
  • To discuss the impact of the Chapel Hill Consensus Conference on nomenclature.

Main Methods:

  • Review of historical and contemporary classification systems for vasculitis.

Related Experiment Videos

  • Analysis of factors influencing classification: vessel size, pathophysiology, and serological markers.
  • Evaluation of diagnostic criteria and nomenclature consensus.

    • Main Results:

    • Multiple classification schemes have been proposed, focusing on vessel size and disease characteristics.
    • American College of Rheumatology criteria aid patient selection for research studies.
    • The Chapel Hill Consensus Conference improved nomenclature for systemic vasculitides.

    Conclusions:

    • Current classification systems for vasculitis have inherent limitations due to incomplete understanding.
    • While nomenclature has been refined, definitive diagnostic criteria for all vasculitis forms are still needed.
    • Further research is essential to develop robust diagnostic and classification tools for vasculitis.