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Related Experiment Videos

Long-term depression at olfactory nerve synapses.

Hiroki Mutoh1, Qi Yuan, Thomas Knöpfel

  • 1Laboratory for Neuronal Circuit Dynamics, Brain Science Institute, The Institute of Physical and Chemical Research (RIKEN), Wako-shi, Saitama 351-0198, Japan.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|April 29, 2005
PubMed
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Olfactory nerve synapses in young mice exhibit long-term depression (LTD) after low-frequency stimulation. This synaptic plasticity in olfactory nerve (ON) to mitral cell (MC) connections may refine odor maps.

Area of Science:

  • Neuroscience
  • Olfactory system plasticity
  • Synaptic plasticity

Background:

  • Olfactory nerve (ON) synapses transmit sensory information to olfactory glomeruli for initial odor processing.
  • Studies suggest plasticity in glomerular odor processing in neonate rodents.
  • Long-term synaptic plasticity has not been previously demonstrated in the ON-to-mitral cell (MC) system.

Purpose of the Study:

  • To investigate the presence and characteristics of long-term synaptic plasticity at ON-to-MC synapses in young mice.
  • To determine the cellular mechanisms underlying observed synaptic plasticity.

Main Methods:

  • Electrophysiological recordings from ON-to-MC synapses in 5- to 8-day-old mice.
  • Low-frequency stimulation of the olfactory nerve.

Related Experiment Videos

  • Pharmacological manipulation to probe receptor involvement.
  • Imaging of presynaptic calcium signals.

    • Main Results:

    • ON-to-MC synapses exhibit long-term depression (LTD) following brief low-frequency ON stimulation.
    • ON-MC LTD is expressed presynaptically.
    • LTD requires activation of metabotropic glutamate receptors.
    • Fast synaptic transmission is not required for ON-MC LTD.

    Conclusions:

    • Long-term depression (LTD) is a form of synaptic plasticity present at ON-to-MC synapses in early development.
    • Presynaptic mechanisms and metabotropic glutamate receptor activation are crucial for ON-MC LTD.
    • This plasticity is potentially important for the formation, maintenance, and refinement of olfactory maps in the olfactory bulb.