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[Seasonal changes in bronchial reactivity in pollinosis patients]
Zenon Siergiejko1, Ewa Swiebocka, Grzegorz Siergiejko
1Klinika Alergologii i Chorób Wewnetrznych Akademii Medycznej w Bialymstoku. siergiejko@csk.pl
The Aim Of The Study:
To evaluate seasonal changes in bronchial hyperreactivity (BHR) in patients suffering from pollinosis, sensitive to Ryegrass engl.
Material And Methods:
The studies were carried out on 26 patients and 20 healthy subjects. All the patients had a history of seasonal allergic rhinitis. The following measurements were performed outside and during the pollen season: bronchial provocation test (BPT) with metacholine and 4.5% NaCl, serum concentration of specific and total IgE.
Results:
Outside the pollen season additionally the BPT with Ryegrass engl. allergen was performed and 88% of the pollinosis patients had positive result of the test. After 4.5% NaCl bronchial challenge positive results had 2 out of 26 patients outside the season, and 3 during the season. Bronchial hyperreactivity to metacholine (PC20 < 8 mg/ml) were observed in 4/26 (15.4%) persons outside the season and in 7 (26.9) during the season. The healthy subjects had no bronchoconstriction neither after metacholine or 4.5% NaCl. During the pollen season the increase in serum concentration of tIgE and sIgE was observed only in pollinosis patient.
Conclusions:
There was not found a correlation between BHR to the allergen and serum total IgE nor specific IgE concentration.
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