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Related Experiment Videos

Glioblastomas in the older old.

B K Kleinschmidt-DeMasters1, K O Lillehei, M Varella-Garcia

  • 1Department of Pathology, University of Colorado Health Sciences Center, Denver, CO 80262, USA. bk.demasters@uchsc.edu

Archives of Pathology & Laboratory Medicine
|April 30, 2005
PubMed
Summary

Epidermal growth factor receptor (EGFR) amplification is a significant predictor of survival in elderly glioblastoma multiforme (GBM) patients over 75. Despite poor overall survival, EGFR amplification correlated with longer survival times in this age group.

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Area of Science:

  • Neuro-oncology
  • Molecular biology
  • Geriatric oncology

Background:

  • Glioblastoma multiforme (GBM) exhibits distinct biological differences in older versus younger patients.
  • High cell cycle labeling indices in older GBM patients are linked to adverse prognosis.
  • Limited data exists for very elderly GBM patients, where these factors may be more pronounced.

Purpose of the Study:

  • To evaluate epidermal growth factor receptor (EGFR) amplification and MIB-1 indices in GBM patients aged over 75.
  • To determine the prognostic significance of these markers in an elderly GBM cohort.

Main Methods:

  • Retrospective analysis of 20 GBM patients (aged 75-87 years).
  • Immunohistochemistry used to assess MIB-1 labeling index (cell proliferation marker).

Related Experiment Videos

  • Fluorescence in situ hybridization (FISH) employed to detect EGFR amplification and chromosome 7 polysomy.

    • Main Results:

    • Mean MIB-1 index was high (24.8%), but did not correlate with survival.
    • EGFR amplification or chromosome 7 gain was present in 95% of patients.
    • EGFR amplification was associated with significantly longer survival (mean 8.3 months) compared to its absence (mean 3.2 months) (P = .04).

    Conclusions:

    • EGFR amplification is a significant predictor of survival in elderly GBM patients.
    • The findings highlight the importance of molecular markers in predicting outcomes for older adults with GBM.