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Hematologic malignancies with primary retroperitoneal presentation: clinicopathologic study of 32 cases
LeiLei Chen1, Philip Kuriakose, Robert C Hawley
1Department of Pathology, Henry Ford Hospital, Detroit, Mich 48202, USA.
Archives of Pathology & Laboratory Medicine
|April 30, 2005
Summary
Primary retroperitoneal lymphoma is rare and challenging to diagnose. Needle biopsy with immunophenotyping is a practical and reliable method for diagnosing these hematologic malignancies.
Area of Science:
- Oncology
- Hematology
- Pathology
Background:
- Primary retroperitoneal lymphoma is an uncommon malignancy.
- Its retroperitoneal location presents diagnostic and management challenges for clinicians and pathologists.
Purpose of the Study:
- To describe the experience with hematologic malignancies primarily presenting in the retroperitoneum.
- To evaluate diagnostic methods for primary retroperitoneal lymphoma.
Main Methods:
- Retrospective review of 32 patients with retroperitoneal masses and hematologic malignancies.
- Histopathology review and classification using the World Health Organization criteria.
- Analysis of diagnostic methods, including needle biopsy and immunophenotyping.
Main Results:
- Diffuse large B-cell lymphoma was the most common type (12/32).
- A variety of B-cell lymphomas, T-cell lymphomas, and Hodgkin lymphomas were identified.
- Over half of the cases (17/32) were diagnosed via needle biopsy with immunophenotyping.
Conclusions:
- Needle biopsy, complemented by flow cytometry and immunohistochemistry, is a practical and reliable diagnostic method for primary retroperitoneal lymphoma.
- While open lymph node biopsy is preferred, minimally invasive techniques are crucial given the location.