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Primary breast lymphoma cytologic diagnosis.
Enver Vardar1, Guliz Ozkok, Mehtap Cetinel
1Department of Pathology, SSK Izmir Teaching Hospital, Izmir, Turkey. envervardar@ttnet.net.tr
Archives of Pathology & Laboratory Medicine
|April 30, 2005
Summary
Bilateral primary non-Hodgkin lymphoma of the breast is exceptionally rare. This case study details a 40-year-old woman diagnosed with diffuse large B-cell lymphoma in both breasts, successfully treated with chemotherapy.
Area of Science:
- Oncology
- Hematology
- Pathology
Background:
- Primary breast lymphoma is a rare malignancy.
- Bilateral involvement of primary breast lymphoma is exceptionally uncommon.
Purpose of the Study:
- To report an exceptional case of bilateral primary non-Hodgkin lymphoma of the breast.
- To highlight the diagnostic and therapeutic considerations for this rare condition.
Main Methods:
- Fine-needle aspiration biopsy of both breasts.
- Incisional biopsy for histopathological confirmation.
- Systemic chemotherapy as treatment.
Main Results:
- Microscopic evaluation revealed predominantly atypical lymphocytes and rare plasma cells.
- Histopathology confirmed non-Hodgkin diffuse large B-cell lymphoma in the left breast.
- The patient achieved remission and remained disease-free for 2 years post-treatment.
Conclusions:
- Bilateral primary non-Hodgkin lymphoma of the breast, though rare, can be effectively managed with systemic chemotherapy.
- Early diagnosis and appropriate treatment are crucial for favorable outcomes in rare breast malignancies.