Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diffusion in three-dimensionally ordered scaffolds with inverted colloidal crystal geometry.

Sachin Shanbhag1, Jung Woo Lee, Nicholas Kotov

  • 1Department of Chemical Engineering, University of Michigan, 3074 H.H. Dow Bldg., 2300 Hayward, Ann Arbor, MI 48109, USA. sachins@engin.umich.edu

Biomaterials
|April 30, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex-specific differences in associations between diet quality and hyperuricemia in Korean adults.

Journal of rheumatic diseases·2026
Same author

Association Between the Use of Proton Pump Inhibitors and Osteoporosis/Fracture: Nested Case-Control Studies Using a National Health Screening Cohort.

Journal of clinical medicine·2026
Same author

Invasive-Front P21 Expression Is Associated With Tumor Aggressiveness in Head and Neck Squamous Cell Carcinoma.

Anticancer research·2026
Same author

Delta Neutrophil Index as an Early Screening and Prognostic Marker for Revision after Non-traumatic Below-Knee Amputation: A Hospital-Based Study.

Clinics in orthopedic surgery·2026
Same author

Multisite Field Evaluation of Oil Accumulation and Agronomic Performance in Grain and Sweet Sorghums Engineered for Lipid Hyperaccumulation.

Plant biotechnology journal·2026
Same author

Platycodin D sensitizes head and neck squamous cell carcinoma to cisplatin by inducing autophagy arrest.

Oncology reports·2026

Inverted colloidal crystal scaffolds hinder nutrient transport, with effective diffusivity reduced to 30% of free solution levels. Larger nutrient particles experience a linear decrease in diffusivity within these 3D structures.

Area of Science:

  • Biomaterials Science
  • Computational Biology
  • Chemical Engineering

Background:

  • Inverted colloidal crystals offer highly organized 3D scaffolds for cell growth.
  • Scaffold regularity facilitates computational analysis of material properties.

Purpose of the Study:

  • To investigate nutrient transport resistance in 3D scaffolds using computational modeling.
  • To quantify effective nutrient diffusivity within inverted colloidal crystal scaffolds.

Main Methods:

  • Brownian dynamics simulations were employed to model nutrient transport.
  • Monte Carlo simulations were used to analyze the effect of particle size on diffusivity.

Main Results:

  • Effective nutrient diffusivity (D_eff) was found to be 0.3 times the free solution diffusivity (D_0) for small nutrients.

Related Experiment Videos

  • Diffusivity decreased linearly with increasing particle size for larger solutes.

    • Conclusions:

    • Inverted colloidal crystal scaffolds significantly impede nutrient diffusion.
    • Scaffold design impacts nutrient transport, a critical factor for cell viability and tissue engineering applications.