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Glucose intolerance and all-cause mortality in Japanese migrants
Suely G A Gimeno1, Katsumi Osiro, Luisa Matsumura
1Preventive Medicine Department, Federal University of São Paulo (UNIFESP-EPM), São Paulo, Brazil. suely@mdprev.epm.br
Objective:
To assess all-cause mortality in a Japanese-Brazilian community according to the categories of glucose tolerance.
Study Design And Setting:
The cohort consisted of participants examined in two phases of a follow-up study started in 1993 (n=647). They were interviewed and submitted to an oral glucose tolerance test. Student's t-test was used to compare baseline parameters between alive and dead subjects. Cox proportional hazards model was used to estimate crude and adjusted hazard ratios (HR).
Results:
Seventy-one deaths occurred during the study period and a higher proportion of men (62%) was detected. Crude all-cause mortality rate was 16.2/1000 person-year. Vascular disease and cancer were the most frequent causes of deaths (77.3%). A higher mortality rate was observed in subjects with diabetes when compared with the normal glucose tolerant ones (HR: 2.0; 95% CI: 1.1-3.6), independently of age, systolic blood pressure, smoking and history of myocardial infarction.
Conclusion:
Also among Japanese living in the Western world, a deleterious role of fasting and 2-h plasma glucose was found on mortality especially among younger subjects.
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