Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Statins effect on smooth muscle cell proliferation.

Stefano Bellosta1, Lorenzo Arnaboldi, Lorenzo Gerosa

  • 1Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy.

Seminars in Vascular Medicine
|April 30, 2005
PubMed
Summary

Statins (3-hydroxy-3-methylglutaryl-coenzyme-A reductase inhibitors) offer cardiovascular benefits beyond cholesterol reduction. They impact vascular smooth muscle cell proliferation, contributing to antiatherosclerotic effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

LDL-cholesterol distance to target: A practical tool for guiding lipid-lowering treatment decisions.

Atherosclerosis plus·2026
Same author

Osmotic Remodeling of Extracellular Vesicles for Precision Nanomedicine.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Corrigendum to "Heated tobacco product aerosol emission compared to cigarette smoke: A scoping review" [Toxicol. Rep. 16 (2026) 102209].

Toxicology reports·2026
Same author

Are we underestimating the benefits of lipid-lowering therapies?

Pharmacological reviews·2026
Same author

Hemostatic Aspects of Interactions Between Anticancer Drugs and Oral Anticoagulants in Patients with Cancer-Associated Venous Thromboembolism.

Seminars in thrombosis and hemostasis·2026
Same author

New frontiers in the treatment of hypercholesterolaemia: oral inhibition of PCSK9.

European heart journal supplements : journal of the European Society of Cardiology·2026

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Biochemistry

Background:

  • Clinical trials confirm statins reduce cardiovascular morbidity and mortality, with benefits observed in patients with and without coronary artery disease.
  • The established mechanism for statins involves inhibiting cholesterol synthesis via 3-hydroxy-3-methylglutaryl-coenzyme-A reductase.
  • Mevalonic acid, a product of this pathway, is a precursor to cholesterol and other non-steroidal isoprenoids, suggesting broader effects.

Purpose of the Study:

  • To explore the pleiotropic effects of statins, focusing on their impact beyond cholesterol lowering.
  • To review clinical and experimental data demonstrating statin effects on arterial smooth muscle cell proliferation.
  • To investigate the contribution of direct vascular effects to the cardiovascular benefits observed with statin therapy.

Related Experiment Videos

Main Methods:

  • Review of clinical trial data on statin efficacy.
  • Analysis of experimental studies investigating the molecular mechanisms of statins.
  • Focus on data related to arterial myocyte migration, proliferation, and cholesterol accumulation.

Main Results:

  • Statins exhibit effects independent of their lipid-lowering properties.
  • Statins can modulate key processes in atherogenesis, including arterial smooth muscle cell proliferation.
  • Evidence suggests direct vascular actions contribute to the antiatherosclerotic benefits of statins.

Conclusions:

  • Statins possess significant pleiotropic effects that extend beyond cholesterol reduction.
  • Direct vascular actions, particularly on smooth muscle cells, are crucial for the antiatherosclerotic effects of statins.
  • Further research is needed to fully elucidate the contribution of these direct vascular effects to overall cardiovascular event reduction.