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Hypercalcemia in a patient with common variable immunodeficiency and renal granulomas
Alex Meyer1, Helen J Lachmann, A David Webster
1Department of Nephrology and Immunology, and Histopathology, Royal Free Hospital, London, United Kingdom. ameyer@doctors.net.uk
Abstract:
Common variable immunodeficiency (CVID) is the most common primary immunodeficiency. A granulomatous form of the condition is recognized. Renal involvement is rare. The authors present the first case of CVID with biopsy-proven noncaseating renal granulomas, in association with hypercalcemia. The mechanism of hypercalcemia in granulomatous disorders, and the difficulty of differentiating granulomatous CVID from sarcoidosis, are discussed.
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