Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Computational analysis of tumor angiogenesis patterns using a two-dimensional model.

Eun Bo Shim1, Young-Guen Kwon, Hyung Jong Ko

  • 1Department of Mechanical and Biomedical Engineering, Kangwon National University, Hyoja-dong, Chuncheon, Kangwon-do 200-701, Korea. ebshim@kangwon.ac.kr

Yonsei Medical Journal
|April 30, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel Tie2xVEGF bispecific antibody fusion demonstrates enhanced therapeutic efficacy through direct Tie2 activation and VEGF neutralization.

Journal of translational medicine·2026
Same author

CU104, a novel barrier function enhancer, improves colitis via modulation of barrier function and immune cell recruitment.

Frontiers in immunology·2026
Same author

The REDD1-NF-κB-miRNAs-eNOS/SIRT1 axis mediates obesity-induced endothelial cell senescence and hypertension.

Nature communications·2026
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

CU06-1004 inhibits the progression of chronic colitis and colitis-associated colorectal cancer by suppressing inflammation.

Frontiers in pharmacology·2025
Same author

Publisher Correction: Alleviation of preeclampsia-like symptoms through PlGF and eNOS regulation by hypoxia- and NF-κB-responsive miR-214-3p deletion.

Experimental & molecular medicine·2024

This study models tumor angiogenesis, showing that endothelial cells consume basic fibroblast growth factor (bFGF), creating a gradient that drives vessel branching near the tumor surface.

Area of Science:

  • Computational biology
  • Mathematical modeling
  • Cancer research

Background:

  • Tumor growth relies on new blood vessel formation (angiogenesis).
  • Tumor angiogenesis is influenced by signaling molecules like basic fibroblast growth factor (bFGF).
  • Understanding vessel development is crucial for cancer treatment strategies.

Purpose of the Study:

  • To simulate tumor angiogenesis using a computational model.
  • To investigate the role of basic fibroblast growth factor (bFGF) in vascular development.
  • To analyze the resulting vascular architecture and tumor growth patterns.

Main Methods:

  • A two-dimensional computational model was developed to simulate tumor angiogenesis.
  • The Galerkin finite element method and a forward Euler scheme were used to solve the governing equations.

Related Experiment Videos

  • A stochastic process model simulated vessel formation and elongation influenced by bFGF gradients.

    • Main Results:

    • Numerical solutions showed that endothelial cells consumed bFGF, leading to its depletion near developing vessels.
    • A sharp bFGF gradient formed at the tumor surface, driving the "brush-border effect" of vascular branching.
    • Asymmetrical tumor growth correlated with increased branching at the tumor periphery.

    Conclusions:

    • bFGF gradients are critical drivers of vascular architecture in tumors.
    • The "brush-border effect" is a direct consequence of localized bFGF consumption.
    • Computational modeling provides insights into the complex dynamics of tumor angiogenesis and growth.