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Related Experiment Videos

[Virus in sheep's skin].

M Ackermann1

  • 1Virologisches Institut der Universität Zürich. email@vetvir.unizh.ch

Schweizer Archiv Fur Tierheilkunde
|May 3, 2005
PubMed
Summary
This summary is machine-generated.

Ovine gamma herpesvirus type 2 (OvHV-2) infects sheep worldwide, causing malignant catarrhal fever (MCF) in other species. Molecular research reveals OvHV-2 transmission routes and its co-evolutionary balance with sheep.

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Area of Science:

  • Veterinary Virology
  • Molecular Biology
  • Immunology

Context:

  • Ovine gamma herpesvirus type 2 (OvHV-2) is a globally prevalent virus in sheep.
  • The virus causes severe disease, malignant catarrhal fever (MCF), in susceptible livestock like cattle, pigs, elk, and bison.
  • OvHV-2 cannot be cultured in vitro, necessitating molecular approaches for research.

Purpose:

  • To investigate the transmission routes and dissemination mechanisms of OvHV-2.
  • To identify viral genes and their roles in host-virus interactions.
  • To understand the co-evolutionary relationship between OvHV-2 and its natural host, sheep.

Summary:

  • OvHV-2 spreads via respiratory and sexual routes, with lambs infected early in life.
  • Latently infected lymphocytes are key for systemic viral dissemination.

Related Experiment Videos

  • Molecular analysis identified immunologically and cell biologically active genes on the viral genome, likely regulating latent infection in sheep.
  • Electron microscopy and immunohistology provided visual evidence of the virus and its antigens in specific cell types.

    • Impact:

    • Findings elucidate the pathogenesis of OvHV-2 and the basis for its latency in sheep.
    • Understanding the co-evolutionary balance may inform strategies to mitigate MCF in naive host species.
    • This research provides a foundation for developing diagnostic and control measures for OvHV-2 infections.