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Biology of chromatin dynamics

Tzung-Fu Hsieh1, Robert L Fischer

  • 1Department of Plant and Microbial Biology, University of California, Berkeley, California 94720-3102, USA. tzungfu@berkeley.edu

Annual Review of Plant Biology
|May 3, 2005
PubMed

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Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
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Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
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Chromatin Packaging02:21

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