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[The differential expression of hypoxia-inducible factor-1alpha in placenta tissues from pregnancy induced
Wei-guang Wu1, Yuan-qing Yao, Dong-hong Li
1Department of Obstetrics and Gynecology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.
Aim:
To explore the differential expression of hypoxia-inducible factor-1alpha (HIF-1alpha) in placenta tissues from pregnancy induced hypertension and normal pregnancy.
Methods:
The expression of HIF-1alpha protein and mRNA was detected by Western blot and real-time PCR, respectively.
Results:
As compared with the expression levels of HIF-1alpha protein and mRNA in placenta tissues from normal pregnancy, those from pregnancy induced hypertension increased notably (P<0.05).
Conclusion:
The high expression of HIF-1alpha in the placenta tissues pregnancy induced may relate with pathogenesis and pathophysiological process of hypertension.
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