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The 6-derivative of beta-cyclodextrin with succinic acid: a new chiral selector for CD-EKC
Vincenzo Cucinotta1, Alessandro Giuffrida, Giuseppe Maccarrone
1Department of Chemical Sciences, University of Catania, Viale A.Doria 6, 95125 Catania, Italy. ecucinotta@unict.it
Abstract:
6-O-Succinil-beta-cyclodextrin (CDsuc6) was synthesized with very good yield by one pot synthesis and characterized by NMR spectroscopy and ESI-MS. It was used as a chiral selector in capillary electrophoresis to resolve catecholamine racemates, namely norepinephrine, epinephrine, terbutaline and norphenilephrine. The CE experiments at pH 5.6 show very promising selector ability by 6-O-succinil-beta-cyclodextrin for the chiral recognition of all the catecholamines tested, while at pH 9.2, only racemic terbutaline was successfully separated.
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