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Synthesis and biological evaluation of gemcitabine-lipid conjugate (NEO6002)
Shoukath M Ali1, Abdul R Khan, Moghis U Ahmad
1NeoPharm Inc., Research and Development Facility, 1850 Lakeside Drive, Waukegan, IL 60085, USA.
Bioorganic & Medicinal Chemistry Letters
|May 3, 2005
Abstract:
A novel gemcitabine-lipid conjugate 5 was synthesized and tested for its in vivo efficacy and toxicity. Compound 5 was tested in BxPC-3 human pancreatic tumor model in SCID mice and exhibited promising activity and lower toxicity when compared with Gemzar.
