Identification of chemokine receptor CCR4 antagonist
Ashok V Purandare1, Aiming Gao, Honghe Wan
1Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543, USA. ashok.purandare@bms.com
Bioorganic & Medicinal Chemistry Letters
|May 3, 2005
Abstract:
The present study reports the identification and hits to leads optimization of chemokine receptor CCR4 antagonists. Compound 12 is a high affinity, non-cytotoxic antagonist of CCR4 that blocks the functional activity mediated by the receptor.
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