Related Experiment Videos
Maternal death after second-trimester genetic amniocentesis.
James A Thorp1, Andrew W Helfgott, Elizabeth A King
1Regional Perinatal Center, Sacred Heart Women's Hospital, Pensacola, USA.
Obstetrics and Gynecology
|May 3, 2005
Summary
A rare maternal death occurred following an uncomplicated second-trimester amniocentesis. This case highlights the potential for serious complications, including sepsis, after the procedure.
Area of Science:
- Perinatal medicine
- Maternal-fetal medicine
- Infectious disease
Background:
- Amniocentesis is a common prenatal diagnostic procedure.
- Complications, though rare, can be severe.
- This case examines a fatal outcome after an otherwise uncomplicated procedure.
Observation:
- A second-trimester amniocentesis was performed using standard sterile technique and ultrasound guidance.
- The amniotic fluid analysis showed no signs of infection.
- The patient developed Escherichia coli sepsis and disseminated intravascular coagulation.
Findings:
- The patient died 40 hours post-procedure from sepsis and disseminated intravascular coagulation.
- Autopsy revealed no evidence of procedural injury to the bowel or other organs.
- The cause of sepsis remains unclear despite a sterile procedure and normal initial fluid analysis.
Implications:
- Obstetric care providers must remain vigilant for potential serious maternal morbidity and mortality.
- Even uncomplicated amniocentesis carries a risk of severe adverse events.
- This case underscores the importance of patient counseling regarding the rare but serious risks associated with amniocentesis.