Maternal death after second-trimester genetic amniocentesis

We report a maternal death after a second-trimester amniocentesis.

An uncomplicated amniocentesis was performed using sterile technique and ultrasound guidance. A refrigerated amniotic fluid specimen demonstrated negative leukocyte esterase activity, negative Gram stain for bacteria and white blood cells, and normal glucose and interleukin-6. The patient died from Escherichia coli sepsis and disseminated intravascular coagulation 40 hours after the amniocentesis. The autopsy showed normal- appearing needle entries into the skin and uterus without evidence of bowel adhesion or a needle track through the bowel.

Genetic counselors and obstetric care providers should be aware of potential serious maternal morbidity and mortality that may occur subsequent to uncomplicated amniocentesis.