Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chickenpox.

Sophie Hambleton1

  • 1Department of pediatrics, Columbia University, College of Physicians & Surgeons, New York, NY 10032, USA. sh2253@columbia.edu

Current Opinion in Infectious Diseases
|May 3, 2005
PubMed
Summary
This summary is machine-generated.

Varicella-zoster virus (VZV) vaccination is effective but breakthrough cases occur. Further research into VZV biology and immune responses is needed for improved prevention and treatment strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease.

The New England journal of medicine·2026
Same author

Treosulfan-fludarabine conditioning in infants with severe combined immunodeficiencies: Extended study of the UK paediatric treosulfan study.

British journal of haematology·2026
Same author

An update on inborn errors of V(D)J recombination.

Physiology (Bethesda, Md.)·2026
Same author

The 2024 update of IUIS phenotypic classification of human inborn errors of immunity.

Journal of human immunity·2026
Same author

Human inborn errors of immunity: 2024 update on the classification from the International Union of Immunological Societies Expert Committee.

Journal of human immunity·2026
Same author

Learning from inborn errors of immunity and secondary immune deficiencies about vaccine immunogenicity, efficacy, and safety.

Clinical and experimental immunology·2025

Area of Science:

  • Virology
  • Immunology
  • Public Health

Background:

  • Varicella-zoster virus (VZV) remains a global health concern despite existing vaccines and antivirals.
  • Universal infant vaccination against VZV was implemented in the US a decade ago, generating valuable epidemiological data.

Purpose of the Study:

  • To review current epidemiological data on VZV vaccination.
  • To discuss recent advances in VZV virology and pathogenesis.
  • To inform decision-making regarding VZV vaccine use globally.

Main Methods:

  • Review of epidemiological data on VZV vaccination in the US.
  • Analysis of recent findings in VZV virology and pathogenesis.
  • Examination of VZV vaccine effectiveness and immune response attrition.

Related Experiment Videos

Main Results:

  • VZV pathogenesis understanding advanced, identifying the mannose 6-phosphate receptor's role.
  • Cloning of the VZV genome and development of latency/reactivation models facilitate future research.
  • US VZV vaccine demonstrates high effectiveness in reducing varicella incidence, hospitalizations, and deaths.
  • Significant rates of breakthrough varicella and potential immune response attrition observed in some vaccinees.

Conclusions:

  • Current VZV prevention and treatment capabilities exceed fundamental knowledge of its pathogenesis and immune mechanisms.
  • Advances in understanding VZV biology are anticipated to drive future clinical progress in managing VZV infections.