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Pathologic features of necrotizing adenoviral prostatitis in an AIDS patient

Dorian Dikov1, François P Chatelet, Jordan Dimitrakov

  • 1Department of Pathology, Hospital Lagny-Marne-La-Valée, Paris, France.

International Journal of Surgical Pathology
|May 3, 2005
PubMed

Insights

This study reports the first case of necrotizing adenoviral prostatitis in an immunocompromised patient with acquired immunodeficiency syndrome (AIDS). Adenovirus infection can manifest in the prostate, a finding crucial for diagnosing prostatic diseases.

Area of Science:

  • Infectious Diseases
  • Pathology
  • Virology

Background:

  • Adenovirus is a known opportunistic pathogen in immunocompromised individuals.
  • Generalized adenoviral infections often lead to multiorgan involvement and poor prognosis.
  • Acquired immunodeficiency syndrome (AIDS) significantly increases susceptibility to opportunistic infections.

Observation:

  • A case of necrotizing adenoviral prostatitis is described in a 35-year-old male patient with terminal AIDS.
  • The patient presented with a generalized adenoviral infection.
  • Histopathological examination of the prostate revealed intraacinar necrotizing inflammation and viral nuclear inclusions.

Findings:

  • Adenovirus was confirmed in the prostate tissue via electron microscopy and immunohistochemistry.
  • The prostate tissue showed a mild inflammatory reaction with T-lymphocytes and macrophages.
  • Squamous metaplasia was observed in adjacent prostate acini.

Implications:

  • This case represents the first documented instance of adenoviral prostatitis in medical literature.
  • Adenoviral prostatitis expands the spectrum of known organ manifestations of adenovirus infection.
  • Necrotizing adenoviral prostatitis should be considered in the differential diagnosis of necrotizing prostatic diseases, particularly in immunocompromised patients.

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