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Histamine in chronic allergic responses.

M Jutel1, K Blaser, C A Akdis

  • 1Swiss Institute of Allergy and Asthma Research (SIAF), Davos, Switzerland.

Journal of Investigational Allergology & Clinical Immunology
|May 4, 2005
PubMed
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Histamine modulates chronic inflammation and immune responses by influencing immune cell activity and T regulatory cell function. Its diverse effects are mediated by four histamine receptors, impacting allergic conditions like asthma.

Area of Science:

  • Immunology
  • Allergy and Inflammation Research
  • Pharmacology

Background:

  • Histamine is known for acute inflammatory and allergic responses.
  • Emerging evidence suggests histamine's role in chronic inflammation and immune regulation.

Purpose of the Study:

  • To highlight novel discoveries in histamine immunobiology.
  • To discuss the relevance of these findings to allergic inflammatory responses.

Main Methods:

  • Review of current literature on histamine's role in immune regulation.
  • Analysis of histamine receptor (HR) expression, signaling, and affinity.
  • Correlation of histamine's effects with experimental asthma models.

Main Results:

Related Experiment Videos

  • Histamine influences immune cell recruitment, maturation, activation, and effector functions in chronic inflammation.
  • Histamine, via HR2, positively interferes with T regulatory cell-induced peripheral tolerance.
  • Histamine regulates antigen-specific T helper 1 (TH1) and T helper 2 (TH2) cells and antibody responses.

    • Conclusions:

    • Differential expression and signaling of four histamine receptors explain histamine's diverse immune effects.
    • Receptor affinity is crucial for histamine's biological actions and the efficacy of targeted drugs.
    • Understanding histamine immunobiology offers insights into managing allergic inflammatory diseases like asthma.