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Thyroid replacement therapy in Down's syndrome with hypothyroidism.

S Korsager, M Andersen

    Journal of Mental Deficiency Research
    |June 1, 1979
    PubMed
    Summary
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    Diagnosing hypothyroidism in elderly individuals with Down syndrome is challenging based on appearance alone. Biochemical thyroid tests are crucial for accurate diagnosis and guiding thyroid replacement therapy.

    Area of Science:

    • Gerontology
    • Endocrinology
    • Genetics

    Background:

    • Elderly individuals with Down syndrome may present with hypothyroidism.
    • Clinical signs of hypothyroidism can be subtle or absent in this population.
    • Accurate diagnosis is essential for appropriate management.

    Purpose of the Study:

    • To investigate the diagnostic challenges of hypothyroidism in elderly Down syndrome patients.
    • To assess the efficacy of thyroid replacement therapy in this cohort.
    • To emphasize the importance of biochemical testing for diagnosis.

    Main Methods:

    • Investigated three elderly subjects with Down syndrome and biochemical hypothyroidism.
    • Assessed clinical appearance, biochemical thyroid values, and intellectual performance.

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  • Monitored changes before and after four months of thyroid replacement therapy.

    • Main Results:

    • Clinical presentation of hypothyroidism varied significantly.
    • Biochemical response to thyroid replacement was similar to normal subjects.
    • Intellectual performance showed minimal to no improvement, but discomfort resolved.

    Conclusions:

    • Diagnosis of hypothyroidism in elderly Down syndrome patients often requires biochemical tests.
    • Thyroid replacement therapy is indicated and beneficial, particularly for symptom relief.
    • Standard treatment protocols for hypothyroidism should be applied to these patients.