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Prevalence of antiphospholipid antibodies is not different in Chilean diabetic patients and normal individuals

Iván G Palomo1, Verónica E Mujica, Marcelo L Alarcón

  • 1Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Universidad de Talca, Casilla N 747, Talca, Chile.

Journal of Diabetes and Its Complications
|May 4, 2005
PubMed

Insights

This study found that 14% of diabetic patients had antiphospholipid (aPL) antibodies, including anticardiolipin and antiprothrombin types. No significant link was found between these antibodies and vascular complications in diabetes.

Area of Science:

  • Immunology
  • Endocrinology
  • Vascular Medicine

Background:

  • Diabetes mellitus (DM) is linked to vascular and neurological issues.
  • Antiphospholipid (aPL) antibodies are associated with thrombosis and pregnancy loss.
  • The connection between aPL antibodies and DM requires further investigation.

Purpose of the Study:

  • To determine the prevalence of aPL antibodies in diabetic patients.
  • To explore potential associations between aPL antibodies and DM complications.

Main Methods:

  • Analyzed 100 Chilean diabetic patients and 100 healthy controls.
  • Tested for IgG, IgM, and IgA anticardiolipin (aCL), anti-beta(2) glycoprotein I (anti-beta(2)GPI), and antiprothrombin (aPT) antibodies.
  • Assessed for lupus anticoagulant (LA) activity.

Main Results:

  • 14% of diabetic patients tested positive for aPL antibodies.
  • Prevalence included aCL (4%), anti-beta(2)GPI (2%), and aPT (9%) antibodies.
  • All patients were LA negative, and antibody activity levels were low.
  • No significant correlation was found between aPL antibodies and vascular complications.

Conclusions:

  • A notable prevalence of aPL antibodies exists in diabetic patients.
  • The detected aPL antibodies did not correlate with vascular complications in this cohort.
  • Further research is needed to clarify the role of aPL antibodies in diabetes.

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