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Chronic lower limb ulcer? No--chloroma!
1Sri Ramachandra Medical College and Research Institute, Deemed University, Chennai, India.
Summary
Extra medullary deposits, also known as granulocytic sarcoma, can manifest in various tissues. This case highlights a chloroma, a rare form of myeloid neoplasia, presenting as a leg ulcer in a patient with chronic myeloid leukemia.
Area of Science:
- Hematology
- Oncology
- Dermatology
Background:
- Extra medullary deposits are frequently linked to myeloproliferative disorders, particularly myeloid neoplasia.
- These deposits have several names including granulocytic sarcoma, chloroma, and myeloblastoma.
- They can occur in diverse locations such as bone, skin, and lymph nodes.
Purpose of the Study:
- To report a case of a patient with a nonhealing lower limb ulcer.
- To investigate the association of the ulcer with extra medullary deposits.
- To determine the underlying hematological malignancy.
Main Methods:
- Clinical case presentation.
- Diagnostic workup including physical examination and imaging.
- Histopathological examination of the ulcer tissue.
- Assessment for underlying hematological conditions.
Main Results:
- A patient with no prior history of neoplasm presented with a nonhealing leg ulcer.
- The ulcer was diagnosed as a chloroma, a type of extra medullary deposit.
- The patient was subsequently diagnosed with chronic myeloid leukemia.
Conclusions:
- Chloroma can be the initial presentation of chronic myeloid leukemia, even without a prior history of neoplasm.
- Extra medullary deposits should be considered in the differential diagnosis of unexplained skin lesions or ulcers.
- Early recognition and diagnosis are crucial for timely management of the associated myeloid neoplasia.