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Updated: Aug 18, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
Evolution of resistance mutations pattern in HIV-1-infected patients during intensification therapy with a boosted
José L Blanco1, M Alejandra Biglia, Mireia Arnedo
1Infectious Diseases Service, IDIBAPS, Hospital Clínic, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
Abstract:
Intensification therapy adding a boosted protease inhibitor (PI) to a failing regimen has the potential to worsen the resistance profile. Sixty-six patients included in four different boosted PI intensification studies were assessed and resistance mutations in the reverse transcriptase and protease genes were evaluated at baseline and 4 weeks after the initiation of the intensification strategy. Only one of the 66 patients developed changes in their pattern of mutations able to generate or increase resistance to new drugs.
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