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High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing
Published on: January 22, 2019
In vitro suppression of latent HIV-1 activation by vitamin E: potential clinical implications
Alonso Heredia1, Charles Davis, Anthony Amoroso
1Division of Clinical Research, Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, MD, USA.
Abstract:
We evaluated the effect of vitamin E in controlling HIV-1 production upon activation of the patients' reservoir of resting CD4 lymphocytes in tissue culture experiments. The addition of vitamin E to patients' cultures resulted in significantly reduced levels of p24 virus production (P = 0.0015). These results suggest that vitamin E supplementation may interfere with the emergence of drug-resistant HIV-1 variants archived in the resting cell reservoir and delay or limit virus rebound upon treatment interruptions.
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