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Ceftriaxone-associated gallbladder pseudolithiasis: report of one case
Hsiu-Huei Wen1, Yao-Kang Huang, Gui-Lin Zheng
1Department of Pediatrics, Ten-Chan Hospital, Tao Yuan, Taiwan. service@tcmg.com.tw
Acta Paediatrica Taiwanica = Taiwan Er Ke Yi Xue Hui Za Zhi
|May 5, 2005
Summary
Ceftriaxone can cause reversible gallbladder precipitates in children, a rare complication in Taiwan. This case highlights the importance of recognizing ceftriaxone-induced pseudolithiasis to avoid unnecessary surgeries.
Area of Science:
- Pediatrics
- Gastroenterology
- Radiology
Background:
- Ceftriaxone is a third-generation cephalosporin antibiotic commonly used for bacterial infections.
- Gallbladder pseudolithiasis, or false gallstones, is a known but rarely reported side effect of ceftriaxone in children.
- Taiwan has limited reported cases of this specific ceftriaxone complication in pediatric patients.
Observation:
- A 5-year-old boy presented with severe Salmonella gastroenteritis requiring treatment with ceftriaxone due to multidrug resistance.
- Gallbladder pseudolithiasis developed five days after the initiation of ceftriaxone therapy.
- The pseudolithiasis resolved completely one month after cessation of the antibiotic treatment.
Findings:
- This case report documents a rare instance of ceftriaxone-associated gallbladder pseudolithiasis in a pediatric patient in Taiwan.
- The condition was reversible, resolving spontaneously after the discontinuation of ceftriaxone.
- The clinical presentation mimicked true cholelithiasis, necessitating careful radiological interpretation.
Implications:
- Pediatricians should maintain a high index of suspicion for ceftriaxone-induced pseudolithiasis in children presenting with gallbladder abnormalities during antibiotic therapy.
- Radiologists must be aware of this potential adverse effect of ceftriaxone to avoid misdiagnosis and unnecessary invasive procedures.
- Early recognition and understanding of this reversible condition can prevent patient anxiety and the avoidance of unnecessary cholecystectomy in pediatric patients.