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Neuroendocrine differentiation in primary Merkel cell carcinoma--possible prognostic significance
Virve Koljonen1, Caj Haglund, Erkki Tukiainen
1Department of Plastic Surgery, Helsinki University Hospital, PO Box 266, FIN 00029 HUS, Helsinki, Finland. virve.koljonen@hus.fi
Background:
The aim of this study was to examine the level of neuroendocrine differentiation to determine its association with clinicopathological parameters.
Patients And Methods:
Twenty-five primary MCC samples were evaluated for neuroendocrine differentiation profiles by immunohistochemistry using antibodies to chromogranin-A, microtubule associated protein-2 and synaptophysin. The data were compared with clinical parameters to find out whether their expression correlates with prognosis.
Results:
In general, MCC shows a high degree of neuroendocrine differentiation. A higher expression of chromogranin-A and synaptophysin associated with benign behaviour. Chromogranin-A appeared to be the most important one in predicting the course of disease.
Conclusion:
Low levels of neuroendocrine differentiation in MCC associates with poor prognosis. Chromogranin-A could be used to identify patients who might benefit from oncological treatments.
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