What's new in the field of prostate cancer chemoprevention?

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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Kanwaljit Mahal1, Javier Hernandez, Joseph W Basler

  • 1Division of Urology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.

Current Urology Reports
|May 5, 2005
PubMed

Insights

Chemoprevention strategies are being explored for various cancers. This review focuses on prostate cancer chemoprevention trials, including the Prostate Cancer Prevention Trial and the Selenium and Vitamin E Cancer Prevention Trial.

Area of Science:

  • Oncology
  • Preventive Medicine

Background:

  • Prostate cancer is a leading malignancy, prompting significant research into preventive strategies.
  • Chemoprevention offers a promising approach to reduce cancer incidence and mortality.

Purpose of the Study:

  • To review current and ongoing chemoprevention trials for prostate cancer.
  • To discuss key trials such as the Prostate Cancer Prevention Trial and the Selenium and Vitamin E Cancer Prevention Trial.
  • To explore the role of cyclooxygenase inhibitors in prostate cancer prevention.

Main Methods:

  • Review of completed, planned, and underway chemoprevention trials.
  • Analysis of data from landmark studies in prostate cancer prevention.
  • Examination of pharmacological agents, including cyclooxygenase inhibitors.

Main Results:

  • Chemoprevention trials for prostate cancer are actively being conducted.
  • Specific trials like the Prostate Cancer Prevention Trial and the Selenium and Vitamin E Cancer Prevention Trial provide valuable insights.
  • Cyclooxygenase inhibitors are under investigation for their preventive potential.

Conclusions:

  • Chemoprevention represents a critical area of research for managing prostate cancer.
  • Further investigation into agents like selenium, vitamin E, and cyclooxygenase inhibitors is warranted.
  • Successful chemoprevention could significantly impact prostate cancer rates.

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