Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic factors in pemphigus.

François Tron1, Danièle Gilbert, Hugo Mouquet

  • 1Unité INSERM 519 - IFRMP 23, Hôpital Charles Nicolle, Faculté Mixte de Médecine et de Pharmacie, 22, Boulevard Gambetta, 76183 Rouen Cedex, France. francois.tron@chu-rouen.fr

Journal of Autoimmunity
|May 5, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Universal strategy to generate lentiviral vectors encoding lethal proteins.

Molecular therapy. Advances·2026
Same author

Genotypic and phenotypic characteristics of CXCR4-using transmitted/founder HIV-1 envelope glycoproteins.

Journal of virology·2026
Same author

Distinct Antibody Signatures to Human Endogenous Retroviruses and Mycobacterium Paratuberculosis in Newly Diagnosed Tunisian Type 1 Diabetes Patients.

Cell biochemistry and biophysics·2026
Same author

Comprehensive analysis of neutrophil immunomodulatory properties and FcR dynamics in HIV-1 infection and therapy.

iScience·2026
Same author

A skin colonizer disrupts inflammatory and humoral immune defenses in hidradenitis suppurativa.

EMBO molecular medicine·2026
Same author

Tunable CAR-NK-92 activity in the tumor microenvironment via a dual ATF4-responsive circuit.

Frontiers in immunology·2026

Genetic factors contribute to pemphigus, an autoimmune disease. Studies link the Major Histocompatibility Complex (MHC) locus and desmoglein 1 gene to its development.

Area of Science:

  • Immunogenetics
  • Dermatology
  • Autoimmune Diseases

Background:

  • Genetic factors are implicated in pemphigus pathogenesis, but precise heritability is unclear.
  • Previous research focused on population studies, particularly case-control designs.
  • Twin concordance studies are lacking to fully establish heritability.

Purpose of the Study:

  • To review and synthesize current knowledge on genetic factors in pemphigus susceptibility.
  • To identify key genes and genetic regions associated with pemphigus vulgaris and pemphigus foliaceus.
  • To suggest future research directions for understanding pemphigus genetics.

Main Methods:

  • Review of epidemiological and family studies on pemphigus.
  • Analysis of case-control association studies.

Related Experiment Videos

  • Examination of studies utilizing microsatellite markers and candidate gene approaches.

    • Main Results:

    • Consistent association of the Major Histocompatibility Complex (MHC) locus, especially HLA class II alleles, with pemphigus.
    • Evidence for other MHC genes contributing to susceptibility.
    • Association of a desmoglein 1 gene variant with pemphigus foliaceus, interacting with MHC class II genes.

    Conclusions:

    • Genetic factors, including MHC and non-MHC genes like desmoglein 1, play a significant role in pemphigus.
    • Further association studies and genome scans are warranted, particularly for endemic pemphigus foliaceus.
    • Understanding genetic contributions is crucial for elucidating pemphigus pathogenesis.