Related Experiment Video
Updated: Aug 18, 2026
Tubal Cytology of the Fallopian Tube as a Promising Tool for Ovarian Cancer Early Detection
Published on: July 25, 2017
Follow-up of cytologic predictions of endocervical glandular abnormalities: histologic outcomes in 123 cases
Jennifer M Roberts1, Julia K Thurloe, Clare Biro
1Mayne Health Laverty Pathology, Sydney, New South Wales, Australia. jennifer.roberts@maynegroup.com
Objectives:
To determine histologic positive predictive values (PPVs) for three categories of cytologic reports of endocervical glandular abnormalities.
Materials And Methods:
We obtained histologic follow-up for 100% of 67 cytologic predictions of adenocarcinoma in situ (AIS) and 82% of 39 predictions of possible AIS (?AIS) made over a 4-year period (1999-2002) and for 25% of 105 atypical endocervical cells (AEC) predictions over a 12-month period (2000). For each category of cytologic report, we determined the histologic yields of high-grade lesions overall and of high-grade glandular lesions.
Results:
PPVs for predictions of AIS and ?AIS for high-grade lesions overall were 91% and 75% (p = .032), respectively, and those for high-grade glandular lesions were 88% and 72% (p = .046), respectively. For a cytologic report of AEC, of those with histologic follow-up, 9% had a high-grade lesion and 7% had a high-grade glandular lesion.
Conclusion:
Cytology can accurately predict AIS.