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Updated: Aug 18, 2026
Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
Published on: January 12, 2022
[Reproducibility of measurements of the peripapillary retinal nerve fibre layer thickness. Optical coherence
R Krist1, E M Hoffmann, O Schwenn
1Augenklinik, Universität, Mainz. krist@augen.klinik.uni-mainz.de
Purpose:
The aim of this study was to compare the intra- and inter-examiner reproducibility of measurements obtained by optical coherence tomography (OCT) and retinal thickness analyzer (RTA).
Patients And Methods:
During a period of 2 months, 22 eyes of 16 patients and 6 healthy subjects were included. Two examiners (EMH, RK) successively performed three measurements of the peripapillary retinal nerve fibre layer (RNFL) thickness with RTA and OCT. The reproducibility of three individual measurements of one examiner (intra-examiner) as well as the reproducibility of the measurements between both examiners (inter-examiner) was evaluated using the Friedman test and sign test.
Results:
The average thickness of the peripapillary RNFL was 154.4 microm for the first investigator (EMH) and 155.1 microm for the other investigator (RK) measured with RTA. The results obtained by OCT were 137.3 microm (EMH) and 138.9 microm (RK), respectively, generally indicating a threefold smaller range. Comparing the three measurements of one single examiner, no appreciable intra-observer dependency neither for RTA (EMH: p=0.19, RK: p=0.95) nor for OCT (EMH: p=0.51, RK: p=0.62) was observed. Inter-examiner analysis for RTA and OCT also revealed an acceptable reproducibility.
Conclusions:
Measurements of peripapillary RNFL thickness using RTA and OCT exhibited intra- and inter-observer agreement.
