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Updated: Feb 12, 2026

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
Published on: March 8, 2015
[Expression of brain-derived neurotrophic factor in hippocampus of ovariectomized mouse]
Da-hua Lu1, De-sen Yang, Dan Liu
1Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha 410013, China.
Objective:
To explore the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus after ovariectomy in mice.
Methods:
BDNF levels were detected by immunohistochemistry combined image analysis in hippocampal CA regions and dentate gyrus of ovariectomized mice.
Results:
The expression of BDNF in hippocampus of mice decreased significantly after the ovariectomy after 4 days. The recovery BDNF expression started 14 days after the ovariectomy and after 28 days, the expression of BDNF in hippocampus recovered to the normal level.
Conclusion:
The decrease of estrogen in ovariectomized mice can weaken the expression of BDNF in hippocampus during the early stage.
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