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Updated: Aug 18, 2026
Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease
Published on: May 22, 2026
[Assessment of left ventricular systolic and diastolic function by Doppler tissue imaging in patients with chronic
Sai-dan Zhang1, Sheng-ling Zhang, Hong-yan Zhou
1Department of Cardiology, Xiangya Hospital, Changsha 410008, China. Zhangsaidanli@126.com
Insights
Pulsed-wave Doppler tissue imaging (PW-DTI) effectively assesses left ventricular systolic and diastolic function in chronic heart failure (CHF) patients by measuring mitral annular velocities (MAV). This method provides valuable insights into cardiac performance in CHF.
Area of Science:
- Cardiology
- Echocardiography
- Medical Imaging
Background:
- Chronic heart failure (CHF) significantly impairs left ventricular function.
- Accurate assessment of systolic and diastolic function is crucial for managing CHF.
- Conventional echocardiography has limitations in fully characterizing regional myocardial function.
Purpose of the Study:
- To evaluate the utility of pulsed-wave Doppler tissue imaging (PW-DTI) for assessing left ventricular systolic and diastolic function in patients with CHF.
- To compare PW-DTI derived mitral annular velocities (MAV) with traditional echocardiographic indices.
Main Methods:
- Mitral annular velocities (MAV) including peak systolic (Sa), early diastolic (Ea), and late diastolic (Aa) velocities were measured using PW-DTI.
- Measurements were performed in 35 patients with CHF and 25 healthy controls.
- Conventional echocardiographic indices of global left ventricular function were also assessed.
Main Results:
- CHF patients exhibited significantly decreased Sa, Ea, Aa, and Ea/Aa ratio compared to healthy subjects (P < 0.01).
- Sa showed a strong linear correlation with left ventricle ejection fraction (LVEF) (r = 0.890, P < 0.01).
- Ea was significantly reduced in all CHF diastolic dysfunction subgroups, while Aa and Ea/Aa were decreased in specific subgroups.
Conclusions:
- MAV measured by PW-DTI is a reliable method for evaluating left ventricular systolic and diastolic function in patients with CHF.
- PW-DTI offers a valuable tool for comprehensive cardiac assessment in CHF management.
Objective:
To investigate the application of pulsed-wave Doppler tissue imaging ( PW-DTI) in evaluating left ventricular systolic and diastolic function in patients with chronic heart failure (CHF).
Methods:
Mitral annular velocities (MAV) were measured by PW-DTI in 35 patients with CHF and 25 healthy subjects. Traditional indices for evaluating the global left ventricular function by conventional echocardiography were also studied as a comparison.
Results:
Peak systolic, peak early diastolic, peak late diastolic mitral annular velocities ( Sa, Ea, Aa), and Ea/Aa ratio progressively decreased in CHF patients compared with the healthy subjects (P <0.01 ). Sa of the mitral annulus correlated linearly with the left ventricle ejection fraction (LVEF) (r =0.890, P < 0.01). Compared with the healthy subjects, Ea in all 3 subgroups of diastolic dysfunction in the CHF group significantly decreased (P <0.01). Aa in 2 subgroups (pseudonormal filling and restrictive filling) decreased (P < 0.01 ) and the decreased Ea/Aa was found in the delayed relaxation and pseudonormal filling subgroups compared with the healthy subjects (P<0.001).
Conclusion:
MAV measured by PW-DTI can be used for assessing the left ventricular systolic and diastolic function in CHF patients.
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