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Related Experiment Videos

Precise nanoliter fluid handling system with integrated high-speed flow sensor.

Carsten Haber1, Marc Boillat, Bart van der Schoot

  • 1Seyonic SA, Neuchâtel, Switzerland.

Assay and Drug Development Technologies
|May 6, 2005
PubMed
Summary

This study presents a novel microfluidic system for precise low-volume liquid handling. An integrated flow sensor and feedback loop ensure accurate micro- to nanoliter dispensing, even with changing liquid viscosity.

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Area of Science:

  • Biotechnology
  • Microfluidics
  • Instrumentation

Background:

  • Accurate low-volume liquid dispensing is critical in various scientific applications.
  • Existing systems often struggle with precision, especially when dealing with variable liquid properties.
  • Real-time feedback control is needed to enhance dispensing accuracy.

Purpose of the Study:

  • To develop an intelligent system for highly accurate micro- to nanoliter liquid delivery.
  • To integrate a miniature flow sensor into a feedback control loop for real-time volume adjustment.
  • To achieve automated compensation for liquid viscosity variations during dispensing.

Main Methods:

  • A micro-solenoid valve is driven by an intelligent feedback control loop.
  • A miniature flow sensor, operating in differential mode, is integrated into the dispensing channel.

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  • The sensor measures flow pulses generated by solenoid valve actuation to determine dispensed volume.

    • Main Results:

    • The integral of the flow pulse directly correlates with the ejected droplet volume.
    • Active control adjusts the solenoid valve, significantly enhancing fluid delivery precision.
    • The system automatically compensates for changes in liquid viscosity.
    • Dispensing data is logged for validation and quality control.

    Conclusions:

    • The developed system offers superior precision and accuracy in micro- to nanoliter liquid handling.
    • Real-time feedback control and viscosity compensation are key innovations.
    • The system provides a reliable method for validating and recording dispensing processes.