Related Experiment Videos
[Continuous enteral nutrition versus single bolus: effects on urine C peptide and nitrogen balance]
Alejandro Sanz París1, Julio Lázaro, Ana Guallar
1Servicio de Endocrinología y Nutrición, Hospital Miguel Servet, Zaragoza, Spain. alesanz@arrakis.es
Background And Objective:
Our study was designed to assess the impact on nitrogen and glucose metabolism when it is administered either as discontinuous or as continuous infusion.
Patients And Method:
We assessed the nutritional efficacy (nitrogen balance) and hyperinsulinism risk (urine C peptide excretion) of enteral nutrition in 23 patients hospitalized because of acute stroke.
Results:
The feeding tolerance of our enteral nutrition protocol (nasoenteric catheter) was full in every patient. The nitrogen balance was positive in both patterns, but the balance in the continuous feeding pattern was better than in the bolus feeding one. On the contrary, the urine C peptide excretion was increased when enteral nutrition was administered intermittently as compared with continuous feeding. Calciuria was greater in the continuous fed pattern than in the bolus feeding.
Conclusions:
Continuous feeding is associated with better nitrogen balance and less urine C peptide excretion than intermittent feeding. These results suggest that continuous feeding would be an interesting choice to improve glucose control in diabetic patients with enteral nutrition.
Related Concept Videos
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube through...
Enteral Nutrition I: Orogastric and Nasogastric Feeding
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
Urinary Tract Calculi IV: Nutrition Therapy and Prevention
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
Continuous Renal Replacement Therapy
One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance
In the one-compartment open model for intravenous (IV) bolus administration, clearance is estimated by dividing the elimination rate by the plasma drug concentration. This equation leverages the elimination rate constant and the apparent...